Advances of epigenetic mechanism of congenital heart disease / 国际儿科学杂志

Epigenetics refers to the heritable changes in gene expression without an alteration in the DNA sequence of the genome.Epigenetic mechanism involves DNA methylation,histone modification,chromatin remodeling,non-coding RNA regulation and so on.Many experimental investigations indicate that the abnormalities in epigenetic regulation during cardiac development may be responsible for the progression of congenital cardiac disease.Based on the four aspects of epigenetic regulation above,this review mainly discusses the advances of epigenetic mechanism of congenital heart disease.